Sublingual buprenorphine used postoperatively: clinical observations and preliminary pharmacokinetic analysis.
نویسندگان
چکیده
منابع مشابه
Pharmaceutical and pharmacokinetic characterization of a novel sublingual buprenorphine/naloxone tablet formulation in healthy volunteers
CONTEXT Bitter taste, as well as dissolve time, presents a significant challenge for the acceptability of formulations for oral transmucosal drug delivery. OBJECTIVE To characterize a novel sublingual tablet formulation of buprenorphine/naloxone with regards to pharmacokinetics, dissolve time and formulation acceptability. METHODS Dry mixing techniques were employed to produce a small and f...
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Background: Acute and chronic pain is prevalent in patients with opioid dependence. Lack of knowledge concerning the complex relationship between pain, opioid use, and withdrawal syndrome can account for the barriers encountered for pain management. This study was designed to evaluate the efficacy of sublingual (SL) buprenorphine for post-operative analgesia, compared with intravenous (IV) morp...
متن کاملBuprenorphine implants for treatment of opioid dependence: randomized comparison to placebo and sublingual buprenorphine/naloxone.
AIMS To evaluate the safety and efficacy of buprenorphine implants (BI) versus placebo implants (PI) for the treatment of opioid dependence. A secondary aim compared BI to open-label sublingual buprenorphine/naloxone tablets (BNX). DESIGN Randomized, double-blind, placebo-controlled trial. Subjects received either four buprenorphine implants (80 mg/implant) (n = 114), four placebo implants (n...
متن کاملAcoustic analysis of vowel segments for clinical purposes: preliminary observations
Sustained phonations of the vowels /a/ and /i/ were recorded from 89 patients with voice disorders, who were divided into five pathological subgroups. In addition, recordings were made from a control group of 23 normophonic participants. All recordings were segmented into onset, steady state, and offset, and analyzed acoustically. Results revealed the following findings: 1) only minor differenc...
متن کاملSublingual Buprenorphine Efficacy in Renal Colic Pain Relief: A Randomized Placebo-Controlled Clinical Trial
INTRODUCTION This study was designed to compare the analgesic efficacy of sublingual (SL) buprenorphine and intravenous (IV) ketorolac for renal colic pain relief. METHODS The present study was carried out as a double-blind, double-dummy randomized clinical trial in patients diagnosed with acute renal colic attending the emergency department. The study subjects were 63 patients with confirmed...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1981
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1981.tb01189.x